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Management of neuroborreliosis in European adult patients

TittelManagement of neuroborreliosis in European adult patients
ForfatterLjostad U, Henriksen TH
Årstall2008
Emner
KommentarVoksne nevroborreliose-pasienter anbefales behandling med to eller tre ukers kur med IV penicillin eller ceftriaxone, som er svært effektive mot neuroborreliose. Oral doxycycline er trolig like effektivt. Rest-plager fem år etter behandling er vanlig, og rapportert hos 25-50% av pasientene.
SammendragOBJECTIVES: To survey present knowledge and controversies in European neuroborreliosis. MATERIAL AND METHODS: The article is based on available literature, own experience, and a speech held by the authors. together on the Norwegian annual neurological meeting. RESULTS: Diagnosis of neuroborreliosis is based on clinical neurological findings, laboratory support of borrelia infection, and indications of causality between neurological findings and borreliosis. In the absence of means to identify B. burgdorferi, antibody tests are used for laboratory diagnosis. Two to three weeks courses of IV penicillin or ceftriaxone are highly effective in neuroborreliosis. Oral doxycyclin is probably equally effective. Remaining symptoms five years after treatment for neuroborreliosis are reported in 25-50% of patients. CONCLUSIONS: We suggest two levels of diagnostic accuracy; definite and possible neuroborreliosis. These case definitions are proposed to make the basis for treatment decisions. The prognosis of neuroborreliosis and pathophysiology of post-treatment conditions need further studies. Extensive treatments with antibiotics are not recommended.
Lenkehttp://ww.ncbi.nlm.nih.gov/pubmed/18439217